Ozone Therapies

Oxidant stress can be explained not only by an excess of free radicals, but rather by a deficiency of anti-oxidant buffers.  FACT:  Every clinical study that has looked at function of anti-oxidant buffering systems in patients with chronic diseases, has reached the same conclusion:  the patients are all in a state of oxidant stress caused by lack of adequate buffering capability.   Thus, therapy must not be aimed at reducing the formation of the presence of oxidants, but rather by the stimulation of the anti-oxidant buffering systems.  In the correct dose, this is exactly what Ozone Therapy does.   

How does OZONE work? 

In our bodies, ozone instantaneously interacts with the double bonds found in amino acids (protein) and lipids (fat) to form peroxides.  These peroxides are what exert the induction effects that are seen with ozone therapy.  These peroxides are found in all living bodily tissue and are referred to as (ozonides).  Ozone (like water) is a magnetic dipolar molecule.  The initial formation of peroxides is one that involves an ionic bond.  The magnetic potential of a dipolar molecule prevents free radical formation in aqueous environments at all pH’s less than 8.  Since this pH is not found in the human body, free radical formation does not occur with the use of ozone.  Peroxides are short chained, thus they can easily penetrate cell membranes and oxidate intracellular NADH and FADH2, giving abundant energy to the cells for days and weeks after the treatment session. 

Toxicity of Ozone…

Ozone respiratory toxicity is grossly overrated.  This is because in order to inhale enough ozone to cause permanent damage to the lungs, one would have to inhale a 20 gamma concentration of ozone for over a minute.   Since the vary first inhalation of 20 gamma concentration will result in severe coughing spasms, more than one inhalation, , mush less a 60 second exposure would be impossible.  Thus, the toxicity of ozone to the lungs is so far above the tolerable levels that it need not be considered except in persons with a history of either broncho constriction or restrictive lung disease. 

Energy Production by Ozone

All chronically ill patients produce insufficient amounts of energy.  This is reflected in a decrease in core body temperature, a decrease in basal metabolic rate and a decrease in ATP production.  There are 3 possible causes for deficient metabolism:  1. Capillary obstruction due to abnormal clotting activation of an immune nature.  2.  Decreased cellular uptake of energy substrates, namely fat and glucose.  (This is related to insulin resistance, diabetes and aging).  3.  Mitochondrial dysfunction.  Mitochondrial dysfunction has several causes including:  1. Decreased ability to break down glucose and fat causing a lack of acetyl coenzyme-A, which results in accumulation of lactic acid, which is responsible for acidosis and exhaustion seen in the chronically ill.  2.  Suppression of the citric acid cycle secondary to lack of acetyl coenzyme-A, production.  3. A decrease in oxidative phosphorylation which is often initiated by viruses, heavy metals, pesticides, petrochemicals and auto-antibodies.  Consider this:  by oxidizing NADH and FADH2 and making energy, ozone therapy can correct all of these mitochondrial lesions.   

Induction affects of Ozonides

  1. Increased Cytokine production resulting in improved immune system regulation

  2. Increased ATP production by 40%.

  3. Increased Acetyl Coenzyme-A.

  4. Increased Stimulation of mitochondrial oxidation.

  5. Increased Oxyhemoglobin dissociation resulting in poor tissue oxygenation.

  6. Increased PaO2 – PvO2 difference.

  7. Increased Cellular immune function.

  8. Increased induction of anti-cancer cytokines: TNF, IFN IL2.

  9. Increased Anti-Oxidant buffering of aerobic cells protecting from chemotherapy and radiation therapy.

  10. Direct contact kills cancer cells.

  11. Prevents Cancer Metastasis. 

  12. Normalizes anaerobic cellular metabolism.

  13. Gives significant pain relief.

  14. Anti-Bacterial (anaerobes), Anti-Fungal, Anti-Viral without development of bacterial resistance.

  15. Normalizes Lipids.  

  16. Enhanced RBC membrane distensibility.

 Ozone Therapy

Everybody  knows and accepts that all disease, whether they are acute or chronic are characterized by free radical oxidant stress.  How then is it possible to reverse a condition of oxidant stress by using an oxidant material?  It doesn’t make any sense.  This is the most common question I hear from those uneducated in oxidative medicine, and I believe the single most important reason why conventional medicine continues to decline to study this medical model.  The facts, although anecdotal are this:  patients with disease characterized by chronic oxidant stress are universally observed to improve when properly administered with oxidant therapy.   Think about it, exercise is also known as oxidative stress…

Let me explain this point. Paracelsus was the first physician to suggest that “like cures like.”  Six hundred years later Pasteur administered anthrax bacteria to patients to cure anthrax.  The idea worked.  In the 20th century, vaccination were developed using the same model.  They work not because they kill the bacteria, but because they stimulate, modulate or activate inherent biological systems capable of killing the offending organism.  The Arndt-Schultz principle clearly states that any substance is stimulating in a small enough dose, modulating in a larger dose and suppressive in a still larger dose.  This is the basic conceptual framework within which one can begin to understand oxidative medicine.  In a small enough dose, oxidants act to stimulate the very anti-oxidant systems that act to control them.  Oxidant stress is not necessarily an excessive amount of oxidants or free radical molecules.


 So, which one do we need -  Oxidants or Anti-Oxidants

The answer is actually both.  In the case of an infection, immune cells produce oxidant materials as part of the immune response.  Exercise produces oxidants.  Ozone produces oxidants.  The levels of these oxidant molecules are controlled by the anti-oxidant buffering systems.  These enzyme systems function similar to a thermostat insuring that the levels of oxidant materials stay within a certain range.  Glutathione Peroxidase, Superoxide Dismutase, and Catalyse are a few these enzymes that are oxidized when they capture oxidants thus becoming reduced or incapable of activity.  Anti-Oxidants such as Vitamin C and E work in a supportive capacity by regenerating reduced glutathione.  Thus these vitamins do not control the oxidants directly; they support the enzymes in regenerating.  Anti-Oxidants and Enzymes are ultimately linked together to stop oxidation but oxidation is needed to cause energy to be produced through these reactions.  Energy is needed and made in every cell in our body.  Lack of energy is the ultimate cause of disease.  Properly applied Ozone Therapy will stimulate the activity of the entire anti-oxidant buffering systems, including Glutathione Peroxidase, Superoxide Dismutase and Catalase. 

Clinical Applications

Clearly, one of the most attractive aspects of ozone therapy is its wide clinical application.  There is an abundance of clinical studies have to do with:  atherosclerosis and circulatory compromise;

Ozone therapy plays a significant role in the management and treatment of chronic fatigue, fibromyalgia, diabetes, cancer, chronic infectious disease, auto-immune disease, immune deficiency disorders, the infirmities of aging, and sickle cell anemia. 

Local or topical treatment regimes reveal efficacy in both bacterial and mycotic dermatological infections, both acute and chronic cystitis (including interstitial cystitis), proctitis and colitis, intestinal parasitic disease, osteoarthritis, cervical and lumber disc disease, osteomyelitis, rotator cuff tear, osteoarthritis of the knee and hip, and acute and chronic dental ostitis.